Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis.
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چکیده
منابع مشابه
Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis.
A physiological role for beta-endorphin in endogenous pain inhibition was investigated by targeted mutagenesis of the proopiomelanocortin gene in mouse embryonic stem cells. The tyrosine codon at position 179 of the proopiomelanocortin gene was converted to a premature translational stop codon. The resulting transgenic mice display no overt developmental or behavioral alterations and have a nor...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1996
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.93.9.3995